SCHEMBL7555487

SCHEMBL7555487

O=C(O)C(Cc1cnc2ccc(OCc3ccc(C(F)(F)F)cc3)cc2c1)Sc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.45
PPARG P37231 5/20 0.43
PPARA Q07869 5/20 0.42
PPARD Q03181 3/20 0.42
PTGES O14684 3/20 0.41
ALOX5 P09917 3/20 0.41
GPR132 Q9UNW8 1/20 0.41
PSEN1 P49768 3/20 0.40
MRGPRX4 Q96LA9 1/20 0.40
PTPN1 P18031 2/20 0.40
MAPT P10636 1/20 0.40
MAOA P21397 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7555489 0.82 PPARG (0.43) PPARGPPARAPTGESALOX5
SCHEMBL7069229 0.81 PPARG (0.52) MAOBPPARGPPARAPPARDALOX5
SCHEMBL7550529 0.80 PTPN1 (0.50) MAOBPPARGPTPN1
SCHEMBL7070132 0.75 KMT2A (0.49) MAOBPPARGPPARAALOX5MRGPRX4
SCHEMBL7066051 0.73 PPARG (0.47) MAOBPPARGPPARAPPARDPTGES
SCHEMBL7556674 0.72 MAOB (0.48) MAOBPTPN1MAPT
SCHEMBL7069231 0.70 PPARG (0.39) PPARGPPARAPTGESALOX5
SCHEMBL7069252 0.68 MAOB (0.44) MAOBPPARGPPARAPPARDALOX5
SCHEMBL20377544 0.68 MAOB (0.75) MAOBPPARAPPARDMRGPRX4
SCHEMBL7550100 0.67 PPARA (0.60) MAOBPPARGPPARAPPARDPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032330-A1 Propionic acid derivatives NOMURA YUTAKA (JP) 2002-03-14 US disclosed
EP-0994095-A1 PROPIONIC ACID DERIVATIVES NIPPON CHEMIPHAR CO., LTD. (JP) 2000-04-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032330-A1 Propionic acid derivatives ABAT, ACAT1, PDXK MAOB 1256/4885PPARG 123/4885PPARA 56/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.