Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6251446 | 0.85 | ADRB2 (0.42) | MAOBMAOACYP19A1ADRB2SIGMAR1 | |
| SCHEMBL6252747 | 0.85 | ADRB2 (0.42) | MAOBMAOACYP19A1ADRB2SIGMAR1 | |
| SCHEMBL6253341 | 0.85 | ADRB2 (0.42) | MAOBMAOACYP19A1ADRB2SIGMAR1 | |
| SCHEMBL8986794 | 0.76 | TAAR1 (0.60) | MAOBMAOAADRB2SIGMAR1TAAR1 | |
| Hydrochloric Acid SCHEMBL11678099 | 0.74 | TAAR1 (0.58) | MAOBMAOAADRB2SIGMAR1TAAR1 | |
| SCHEMBL29684100 | 0.72 | MAOB (0.59) | MAOBMAOACYP19A1SIGMAR1TAAR1 | |
| SCHEMBL6678878 | 0.72 | MAOB (0.59) | MAOBMAOACYP19A1SIGMAR1TAAR1 | |
| SCHEMBL8981465 | 0.72 | MAOA (0.50) | MAOBMAOACYP19A1SIGMAR1ALDH1A1 | |
| SCHEMBL6254435 | 0.70 | CYP3A4 (0.37) | ADRB2ALDH1A1CYP2D6HTR1DHTR1B | |
| SCHEMBL13622490 | 0.69 | MAOA (0.60) | MAOBMAOACYP19A1SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |