Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644502 | 0.88 | KMT2A (0.48) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL30670482 | 0.86 | LMNA (0.46) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL4561863 | 0.81 | CHRM2 (0.51) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL20293767 | 0.79 | MAPT (0.47) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL9256005 | 0.77 | KMT2A (0.44) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL9068153 | 0.76 | TSHR (0.47) | KMT2AMAPTLMNACHRM2OPRK1 | |
| SCHEMBL2819529 | 0.74 | CES1 (0.45) | LMNAKCNH2ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL19205720 | 0.73 | SCN5A (0.54) | KMT2AMAPTLMNACHRM2CHRM1 | |
| SCHEMBL2443032 | 0.73 | CHRM2 (0.54) | KMT2ALMNACHRM2CHRM1CHRM3 | |
| SCHEMBL27994258 | 0.73 | ALDH1A1 (0.41) | KMT2AMAPTLMNACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002074763-A9 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | claimed |
| EP-1263724-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062728-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |