Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30670482 | 0.89 | LMNA (0.46) | TSHRLMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL1470605 | 0.87 | TSHR (0.44) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL10609830 | 0.87 | TSHR (0.44) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL10433557 | 0.83 | SMN1; SMN2 (0.41) | TSHRLMNAALDH1A1CYP3A4MAPK1 | |
| SCHEMBL28598274 | 0.83 | TSHR (0.49) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL4041867 | 0.81 | TSHR (0.47) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL9623042 | 0.81 | TSHR (0.47) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL2819529 | 0.80 | CES1 (0.45) | TSHRLMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL27994258 | 0.80 | ALDH1A1 (0.41) | TSHRLMNAALDH1A1MEN1CHRM2 | |
| SCHEMBL1165789 | 0.79 | TSHR (0.46) | TSHRLMNAALDH1A1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536960-B1 | Preparation of 2-hydroxymandelic acids and 2-hydroxybenzaldehydes | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5248816-A | From glycolic acid and borate | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-09-28 | — | — | US | disclosed |
| EP-0536960-A2 | Preparation of 2-hydroxymandelic acids and 2-hydroxybenzaldehydes | ZENECA LIMITED (GB) | 1993-04-14 | — | — | EP | disclosed |