Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27405624 | 0.83 | CA2 (0.44) | — | |
| SCHEMBL2578166 | 0.81 | MAPK8 (0.52) | PARP1PARP15PARP14PARP10EGFR | |
| SCHEMBL7770956 | 0.78 | LMNA (0.46) | SIGMAR1 | |
| SCHEMBL1539285 | 0.74 | TAAR1 (0.52) | TAAR1 | |
| SCHEMBL7557354 | 0.73 | PLA2G2A (0.53) | — | |
| SCHEMBL80602 | 0.72 | — | — | |
| SCHEMBL29427107 | 0.72 | — | — | |
| SCHEMBL10339219 | 0.72 | CA2 (0.54) | — | |
| SCHEMBL9200966 | 0.72 | TAAR1 (0.60) | HCAR2TAAR1 | |
| Trifluoroacetic Acid SCHEMBL5657671 | 0.72 | EGFR (0.46) | PARP1PARP15PARP14PARP10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946495-B1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6353128-B1 | FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK. | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0946495-A4 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0946495-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024756-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |