Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7558666 | 1.00 | TSHR (0.37) | TSHRHPGDALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL2835327 | 0.80 | PTGS2 (0.47) | TSHRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7025060 | 0.78 | KMT2A (0.46) | TSHRHPGDALDH1A1THRBKDM4E | |
| SCHEMBL4928302 | 0.76 | ELANE (0.42) | TSHRHPGDALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11714965 | 0.76 | ALDH1A1 (0.50) | TSHRHPGDALDH1A1MAPK1NPC1 | |
| SCHEMBL19679785 | 0.74 | KMT2A (0.53) | HPGDALDH1A1SMN1; SMN2HSD17B10ALOX15 | |
| SCHEMBL27674000 | 0.73 | ALOX15 (0.46) | TSHRHPGDALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL23582855 | 0.72 | ALOX15 (0.41) | TSHRALDH1A1NPC1RAB9ATHRB | |
| SCHEMBL8791825 | 0.71 | ALDH1A1 (0.47) | HPGDALDH1A1SMN1; SMN2NPC1KDM4E | |
| SCHEMBL12715457 | 0.71 | KDM4E (0.64) | TSHRHPGDALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223168-A1 | Method for the preparation of enantiomerically enriched amino and hydroxyfuranones | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2002-07-17 | — | — | EP | disclosed |
| US-6417377-B1 | Process for preparing enantiomer-enriched amino- and hydroxyfuranones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2002-07-09 | — | — | US | disclosed |