Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxatomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.98 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | MLNR | O43193 | 1/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | DRD2 | P14416 | 1/20 | 0.98 |
| ▸ | PKM | P14618 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxatomide SCHEMBL11199692 | 0.99 | P2RX7 (0.95) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Oxatomide SCHEMBL29484467 | 0.99 | P2RX7 (1.00) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Oxatomide SCHEMBL28824 | 0.99 | P2RX7 (1.00) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Oxatomide SCHEMBL8693540 | 0.98 | P2RX7 (0.98) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Water SCHEMBL11197270 | 0.98 | P2RX7 (0.98) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Oxatomide SCHEMBL8693571 | 0.98 | P2RX7 (0.98) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Water SCHEMBL11197269 | 0.98 | P2RX7 (0.98) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Oxatomide SCHEMBL11472510 | 0.98 | P2RX7 (0.98) | P2RX7LMNAMEN1MLNRNR1I2 | |
| SCHEMBL11198903 | 0.96 | P2RX7 (1.00) | P2RX7LMNAMEN1MLNRNR1I2 | |
| Hydrochloric Acid SCHEMBL11195765 | 0.95 | P2RX7 (0.96) | P2RX7LMNAMEN1MLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165056-A2 | A PROCESS FOR THE MICROENCAPSULATION OF MEDICAMENTS | Pharmaplus S.r.l. (IT) | 2002-01-02 | — | — | EP | claimed |
| WO-2000061119-A2 | A PROCESS FOR THE MICROENCAPSULATION OF MEDICAMENTS | PHARMAPLUS S.R.L. (IT) | 2000-10-19 | — | — | WO | claimed |
| JP-8208624-A | — | — | None | — | — | JP | disclosed |
| JP-H08208624-A | NEW LOW MELTING POINT CRYSTAL OF OXATOMIDE AND ITS PRODUCTION | SUMIKA FINE CHEM KK | 1996-08-13 | — | — | JP | disclosed |
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |