Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24035529 | 0.67 | TGFBR1 (0.38) | — | |
| SCHEMBL9267895 | 0.66 | NPC1 (0.36) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL1127461 | 0.63 | PTGS2 (0.42) | ALOX5PTGS1PTGS2 | |
| SCHEMBL28304521 | 0.57 | ALDH1A1 (0.52) | PTGS2 | |
| SCHEMBL4331066 | 0.57 | ALDH1A1 (0.42) | LMNARAB9A | |
| SCHEMBL9458564 | 0.55 | ALDH1A1 (0.49) | PTGS2LMNARAB9A | |
| SCHEMBL23561017 | 0.55 | GRM5 (0.54) | RAB9A | |
| SCHEMBL29279313 | 0.54 | ALDH1A1 (0.44) | LMNARAB9A | |
| SCHEMBL8041604 | 0.54 | TSHR (0.50) | LMNARAB9A | |
| Biphenyl SCHEMBL2521582 | 0.54 | ALDH1A1 (0.75) | LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1266152-C | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2006-07-26 | — | — | CN | disclosed |
| CN-1545516-A | Process for producing 6- (4-chlorophenyl) -2, 2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-ylacetic acid | ��Ĭ���� | 2004-11-10 | — | — | CN | disclosed |
| WO-2001005792-A9 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |