Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | IDH2 | P48735 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527253 | 0.83 | MAPT (0.60) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL7557829 | 0.82 | KMT2A (0.43) | KIF11DHODHMEN1KMT2AMAPT | |
| SCHEMBL15913218 | 0.77 | KIF11 (0.53) | KIF11ADORA2AIDH2DHODHALDH1A1 | |
| SCHEMBL7520161 | 0.74 | KIF11 (0.52) | KIF11ADORA2AIDH2DHODHALDH1A1 | |
| SCHEMBL7528061 | 0.74 | KIF11 (0.52) | KIF11ADORA2AIDH2DHODHRAPGEF4 | |
| SCHEMBL15992074 | 0.74 | KIF11 (0.52) | KIF11ADORA2AIDH2DHODHALDH1A1 | |
| SCHEMBL394991 | 0.74 | KIF11 (0.70) | KIF11THRBADORA2AIDH2ALDH1A1 | |
| SCHEMBL15913806 | 0.72 | ALDH1A1 (0.47) | KIF11ADORA2AIDH2DHODHALDH1A1 | |
| SCHEMBL17477726 | 0.72 | KIF11 (0.50) | KIF11ADORA2AIDH2DHODHALDH1A1 | |
| SCHEMBL19409877 | 0.72 | IDH2 (0.53) | KIF11ADORA2AIDH2DHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |