Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553515 | 0.97 | P2RX7 (0.58) | P2RX7ADRB1CHRM3MEN1KMT2A | |
| SCHEMBL7554565 | 0.91 | P2RX7 (0.51) | P2RX7ADRB1CHRM3MEN1KMT2A | |
| SCHEMBL7554812 | 0.86 | P2RX7 (0.45) | P2RX7MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL3951445 | 0.83 | P2RX7 (0.64) | P2RX7CHRM3 | |
| SCHEMBL7661977 | 0.81 | P2RX7 (0.61) | P2RX7CHRM3MEN1KMT2ASIGMAR1 | |
| SCHEMBL8081000 | 0.78 | CA1 (0.55) | P2RX7MEN1KMT2ATP53LMNA | |
| SCHEMBL7559466 | 0.78 | DRD3 (0.46) | P2RX7ADRB1CHRM3KMT2AHTR1A | |
| SCHEMBL7552675 | 0.78 | P2RX7 (0.41) | P2RX7MEN1KMT2ASLC6A4 | |
| SCHEMBL7658512 | 0.77 | P2RX7 (0.54) | P2RX7MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL7517095 | 0.77 | P2RX7 (0.39) | P2RX7CHRM3MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |