Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 6/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696460 | 0.83 | CYP19A1 (0.45) | GRM5GAANR1H2NR1H3MEN1 | |
| SCHEMBL2115672 | 0.81 | CACNA1G (0.47) | ALDH1A1NR1H2NR1H3 | |
| SCHEMBL694365 | 0.77 | ALDH1A1 (0.56) | PTGER1HTR1ADRD2ALDH1A1POLB | |
| SCHEMBL12468720 | 0.75 | ALDH1A1 (0.38) | GRM5ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL2114944 | 0.71 | MEN1 (0.37) | ALDH1A1LMNASMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL18762166 | 0.70 | PTGER1 (0.78) | PTGER1ALDH1A1LMNAMAPTSTAT3 | |
| SCHEMBL15162641 | 0.69 | CACNA1G (0.38) | GRM5ALDH1A1POLBGAALMNA | |
| SCHEMBL4095690 | 0.68 | PTGER1 (0.64) | PTGER1 | |
| SCHEMBL561255 | 0.67 | SMN1; SMN2 (0.58) | PTGER1ALDH1A1GAALMNAMAPT | |
| SCHEMBL14124890 | 0.67 | KMT2A (0.48) | GRM5ALDH1A1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399436-B2 | N-pyrazolyl carboxamides as CRAC channel inhibitors | GLAXO GROUP LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
| US-20100273744-A1 | COMPOUNDS | GORE PAUL MARTIN | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | ORAI1, TRPV1, CACNA1E | PTGER1 627/4885GRM5 1007/4885HTR1A 1769/4885 |
| US-20100273744-A1 | COMPOUNDS | LTC4S, HRH4, HRH2 | PTGER1 247/4885GRM5 1775/4885HTR1A 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.