Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Troxacitabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 known ✓ | P09884 | 1/20 | 0.39 |
| ▸ | POLG | P54098 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.50 |
| ▸ | P2RY2 | P41231 | 5/20 | 0.45 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Troxacitabine SCHEMBL17542009 | 0.91 | LMNA (0.56) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL30317744 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL6424800 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL1653267 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL1026150 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL18548 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL1844439 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL1026148 | 0.89 | LMNA (0.60) | POLGPOLBLMNAPDE3ACACNA1F | |
| Troxacitabine SCHEMBL22285889 | 0.88 | LMNA (0.59) | POLGPOLBLMNAPDE3ACACNA1F | |
| Zalcitabine SCHEMBL6066360 | 0.82 | POLG (0.65) | POLGPOLBLMNAPDE3ACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225899-A2 | METHOD FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTION USING NUCLEOSIDE ANALOGUES | Virochem Pharma Inc. (CA) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032153-A2 | METHOD FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTION USING NUCLEOSIDE ANALOGUES | SHIRE BIOCHEM INC. (CA) | 2001-05-10 | — | — | WO | disclosed |