Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.49 |
| ▸ | RXRG | P48443 | 12/20 | 0.49 |
| ▸ | RXRB | P28702 | 11/20 | 0.49 |
| ▸ | RARA | P10276 | 6/20 | 0.41 |
| ▸ | RARB | P10826 | 5/20 | 0.41 |
| ▸ | RARG | P13631 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7558828 | 0.86 | RXRA (0.43) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7558937 | 0.78 | RXRA (0.48) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7558942 | 0.78 | RXRA (0.48) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7558312 | 0.73 | RXRA (0.41) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7559396 | 0.73 | RXRA (0.47) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7562936 | 0.71 | RXRA (0.40) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7562932 | 0.71 | RXRA (0.40) | RXRARXRGRXRBRARARARB | |
| SCHEMBL9097814 | 0.71 | RXRA (0.47) | RXRARXRGRXRBRARARARB | |
| SCHEMBL24005610 | 0.67 | RXRA (0.50) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7897311 | 0.67 | RXRA (0.51) | RXRARXRGRXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986537-B1 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2002-08-07 | — | — | EP | claimed |
| EP-0986537-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | Galderma Research & Development, S.N.C. (FR) | 2000-03-22 | — | — | EP | claimed |
| WO-1999050239-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 1999-10-07 | — | — | WO | claimed |
| EP-0986537-B1 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2002-08-07 | — | — | EP | disclosed |
| EP-0986537-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | Galderma Research & Development, S.N.C. (FR) | 2000-03-22 | — | — | EP | disclosed |
| WO-1999050239-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 1999-10-07 | — | — | WO | disclosed |