Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.81 |
| ▸ | CES1 | P23141 | 3/20 | 0.81 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2156563 | 0.90 | CES2 (1.00) | CES2CES1CA1CA2NPC1 | |
| Hydrochloric Acid SCHEMBL905770 | 0.88 | CES2 (0.96) | CES2CES1CA1CA2NPC1 | |
| Bromide SCHEMBL981452 | 0.88 | CES2 (0.96) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL8652128 | 0.85 | CES2 (0.81) | CES2CES1CA1CA2NPC1 | |
| Benzoic Acid SCHEMBL29612332 | 0.85 | CES2 (0.89) | CES2CES1CA1CA2NPC1 | |
| Benzil SCHEMBL27611875 | 0.85 | CES2 (0.89) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL6618691 | 0.82 | CES2 (0.77) | CES2CES1CA1CA2NPC1 | |
| Benzophenone SCHEMBL27935236 | 0.82 | CES2 (0.77) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL50261 | 0.82 | CES2 (0.77) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL9804961 | 0.81 | CES2 (0.76) | CES2CES1CA1CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891961-B | Improved process for the preparation of imaelstat | 美国杰龙生物医药公司 | 2023-06-30 | — | — | CN | claimed |
| US-5789576-A | DIASTEREOSPECIFIC DIMERIZATION USING ALKOXYMAGNESIUM HALIDE REACTANT; USED FOR SOLID PHASE SYNTHESIS OF ANTISENSE OLIGONUCLEOTIDES | GENTA INCORPORATED (US) | 1998-08-04 | — | — | US | claimed |
| US-5166330-A | Phosphonation, amination and reaction with nucleosides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | claimed |
| EP-0136543-B1 | METHOD FOR THE PREPARATION OF NUCLEOSIDEALKYL, ARALKYL AND ARYL PHOSPHONITES AND PHOSPHONATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-23 | — | — | EP | claimed |
| EP-0136543-A2 | Method for the preparation of nucleosidealkyl, aralkyl and aryl phosphonites and phosphonates | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-10 | — | — | EP | claimed |
| CN-117357548-A | Oligonucleotide composition and method for preparing same | 美国杰龙生物医药公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-111228288-B | Oligonucleotide composition and method for preparing same | 美国杰龙生物医药公司 | 2023-10-20 | — | — | CN | disclosed |
| EP-0850248-B1 | COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES | POLSKA AKAD NAUK CENTRUM (PL) | 2002-07-24 | — | — | EP | disclosed |
| US-5856465-A | NUCLEOSIDE INTERMEDIATES | POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) | 1999-01-05 | — | — | US | disclosed |
| US-5789576-A | DIASTEREOSPECIFIC DIMERIZATION USING ALKOXYMAGNESIUM HALIDE REACTANT; USED FOR SOLID PHASE SYNTHESIS OF ANTISENSE OLIGONUCLEOTIDES | GENTA INCORPORATED (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0850248-A1 | COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES | POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997009340-A1 | COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES | POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) | 1997-03-13 | — | — | WO | disclosed |
| US-5166330-A | Phosphonation, amination and reaction with nucleosides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| EP-0136543-B1 | METHOD FOR THE PREPARATION OF NUCLEOSIDEALKYL, ARALKYL AND ARYL PHOSPHONITES AND PHOSPHONATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-23 | — | — | EP | disclosed |
| EP-0136543-A2 | Method for the preparation of nucleosidealkyl, aralkyl and aryl phosphonites and phosphonates | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-10 | — | — | EP | disclosed |