Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 0.74 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010497 | 0.85 | MTNR1A (1.00) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 | |
| SCHEMBL7526968 | 0.84 | MTNR1A (0.73) | MTNR1AMTNR1B | |
| SCHEMBL7561873 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BNPC1 | |
| SCHEMBL7520573 | 0.79 | MTNR1A (0.73) | MTNR1AMTNR1B | |
| SCHEMBL10244178 | 0.78 | MTNR1A (0.59) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7522947 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL7523147 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 | |
| SCHEMBL1011204 | 0.75 | MTNR1A (0.82) | MTNR1AMTNR1B | |
| SCHEMBL8736674 | 0.75 | MTNR1A (0.61) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7526482 | 0.74 | MTNR1A (0.85) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |