Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555469 | 0.85 | CRHR1 (0.58) | CRHR1TDP1DPP4CYP1A2CYP2A6 | |
| SCHEMBL7684798 | 0.84 | CRHR1 (0.51) | CRHR1DPP4CYP1A2CYP2A6 | |
| SCHEMBL7788894 | 0.78 | CRHR1 (0.62) | CRHR1TDP1 | |
| SCHEMBL7681407 | 0.78 | CRHR1 (0.54) | CRHR1TDP1CYP1A2 | |
| SCHEMBL226802 | 0.78 | CRHR1 (0.77) | CRHR1TDP1 | |
| SCHEMBL7682689 | 0.78 | CRHR1 (0.51) | CRHR1CYP1A2 | |
| SCHEMBL7677531 | 0.77 | CRHR1 (0.53) | CRHR1TDP1DPP4CYP1A2CYP2A6 | |
| SCHEMBL6092339 | 0.77 | CRHR1 (0.57) | CRHR1TDP1 | |
| SCHEMBL7557048 | 0.77 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL7788887 | 0.77 | CRHR1 (0.55) | CRHR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-20020019406-A1 | 9H-pyrimido[4,5-b]indole derivatives: CRF1 specific ligands | NEUROGEN CORPORATION | 2002-02-14 | — | — | US | disclosed |
| US-20010031758-A1 | Substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives: selective neuropeptide Y receptor ligands | NEUROGEN CORPORATION | 2001-10-18 | — | — | US | disclosed |
| US-6284766-B1 | DIAGNOSIS, THERAPY OF STRESS DISORDERS | NEUROGEN CORPORATION | 2001-09-04 | — | — | US | disclosed |
| US-6221875-B1 | TREATING FEEDING DISORDERS, OBESITY, BULIMIA NERVOSA OR HYPERTENSION IN A MAMMAL | NEUROGEN CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019406-A1 | 9H-pyrimido[4,5-b]indole derivatives: CRF1 specific ligands | HTR1D, CRHR1, HTR1A | CRHR1 2/4885TDP1 2969/4885DPP4 1652/4885 |
| US-20010031758-A1 | Substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives: selective neuropeptide Y receptor ligands | NPY1R, NPY2R, NPY5R | CRHR1 33/4885TDP1 2365/4885DPP4 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.