Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7426893 | 0.98 | L3MBTL1 (0.50) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL21358044 | 0.84 | KDM4E (0.39) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL128967 | 0.83 | L3MBTL1 (0.55) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL535668 | 0.82 | L3MBTL1 (0.58) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL8579294 | 0.81 | KDM4E (0.62) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL28677368 | 0.81 | L3MBTL1 (0.57) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL25414723 | 0.80 | L3MBTL1 (0.55) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL12948310 | 0.80 | L3MBTL1 (0.55) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL18216628 | 0.80 | L3MBTL1 (0.55) | L3MBTL1PARP1KDM4EMPOALDH1A1 | |
| SCHEMBL1979301 | 0.80 | L3MBTL1 (0.55) | L3MBTL1PARP1KDM4EMPOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12215116-B2 | Arginase inhibitors and methods of use | MERCK SHARP & DOHME LLC (US) | 2025-02-04 | — | — | US | disclosed |
| US-20210040127-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2021-02-11 | — | — | US | disclosed |
| US-20210040127-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2021-02-11 | — | — | US | disclosed |
| EP-3765006-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp&Dohme Corp. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |
| EP-0801648-A4 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0801648-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5556909-A | PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI WINTHROP INC. (US) | 1996-09-17 | — | — | US | disclosed |
| WO-1996016951-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040127-A1 | ARGINASE INHIBITORS AND METHODS OF USE | ARG1, ARG2, PRMT1 | L3MBTL1 4590/4885PARP1 3613/4885KDM4E 3142/4885 |
| US-12215116-B2 | Arginase inhibitors and methods of use | ARG1, ARG2, PRMT1 | L3MBTL1 4590/4885PARP1 3613/4885KDM4E 3142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.