Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563165 | 0.76 | CRHR1 (0.33) | PKMCRHR1KDM4E | |
| SCHEMBL7565694 | 0.74 | ALDH1A1 (0.37) | CRHR1KDM4EHTTCHRM4HSD17B10 | |
| SCHEMBL7562834 | 0.71 | CRHR1 (0.45) | CRHR1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL7564260 | 0.69 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7590936 | 0.68 | PDE1B (0.39) | CRHR1TP53 | |
| SCHEMBL11471053 | 0.67 | HTT (0.58) | NPC1PKMMAPTKDM4ELMNA | |
| SCHEMBL5785442 | 0.67 | CRHR1 (0.36) | CRHR1KDM4ESMN1; SMN2HSD17B10TSHR | |
| SCHEMBL7563197 | 0.66 | CRHR1 (0.40) | NPC1CRHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL7562041 | 0.66 | CRHR1 (0.47) | CRHR1TDP1 | |
| SCHEMBL7562809 | 0.66 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020065290-A1 | Novel deazapurine derivatives: a new class of CRF1 specific ligands | NEUROGEN CORPORATION | 2002-05-30 | — | — | US | claimed |
| EP-0770080-B1 | NOVEL DEAZAPURINE DERIVATIVES; A NEW CLASS OF CRF1 SPECIFIC LIGANDS | NEUROGEN CORP (US) | 1999-07-14 | — | — | EP | claimed |
| US-5644057-A | Deazapurine derivatives; a new class of CRF1 specific ligands | NEUROGEN CORPORATION (US) | 1997-07-01 | — | — | US | claimed |
| US-6495688-B2 | USED AS CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS, IN THERAPY AND DIAGNOSIS OF STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION | 2002-12-17 | — | — | US | disclosed |
| US-20020065290-A1 | Novel deazapurine derivatives: a new class of CRF1 specific ligands | NEUROGEN CORPORATION | 2002-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065290-A1 | Novel deazapurine derivatives: a new class of CRF1 specific ligands | CRHR1, CRH, CRHR2 | NPC1 2470/4885PKM 3826/4885CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.