Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 6/20 | 0.33 |
| ▸ | DRD3 | P35462 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562609 | 0.86 | TRIM24 (0.48) | POLBTRIM24 | |
| SCHEMBL7562605 | 0.77 | ROCK2 (0.35) | POLBTRIM24KMT2ADRD2DRD3 | |
| SCHEMBL7828478 | 0.76 | TACR1 (0.59) | CYP2D6TACR1HTR2A | |
| SCHEMBL6229464 | 0.76 | TACR1 (0.59) | CYP2D6TACR1HTR2A | |
| SCHEMBL1626959 | 0.75 | KMT2A (0.53) | POLBTACR1KMT2AGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6228510 | 0.75 | TACR1 (0.58) | CYP2D6TACR1HTR2A | |
| Hydrochloric Acid SCHEMBL8592303 | 0.75 | TACR1 (0.58) | CYP2D6TACR1HTR2A | |
| SCHEMBL8328961 | 0.74 | TACR1 (0.53) | TACR1KMT2AGAADRD2MEN1 | |
| SCHEMBL8328962 | 0.74 | TACR1 (0.53) | TACR1KMT2AGAADRD2MEN1 | |
| Hydrochloric Acid SCHEMBL6902564 | 0.74 | MEN1 (0.37) | POLBTACR1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175417-A1 | SUBSTITUTED BENZOLACTAM COMPOUNDS | Pfizer Products Inc. (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000068224-A1 | SUBSTITUTED BENZOLACTAM COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2000-11-16 | — | — | WO | disclosed |