Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607688 | 0.75 | MAPK1 (0.52) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL6262302 | 0.75 | CA1 (0.45) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL1538287 | 0.74 | HSD17B10 (0.56) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL677959 | 0.74 | HSD17B10 (0.56) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL397351 | 0.74 | HSD17B10 (0.56) | HSD17B10ACHEALDH1A1HSD11B1MAPT | |
| SCHEMBL6671840 | 0.74 | HSD17B10 (0.56) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| Methoxymethane SCHEMBL27492761 | 0.73 | ALDH1A1 (0.51) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL28551166 | 0.72 | HSD17B10 (0.54) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL6262303 | 0.72 | CA1 (0.53) | HSD17B10ACHEALDH1A1POLBHSD11B1 | |
| SCHEMBL2163539 | 0.72 | ALDH1A1 (0.50) | HSD17B10ACHEALDH1A1POLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764152-B1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-07-31 | — | — | EP | claimed |
| EP-0764152-B1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-07-31 | — | — | EP | disclosed |
| EP-0853614-B1 | SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-10-04 | — | — | EP | disclosed |
| US-6147073-A | IMPROVED BIOAVAILABILITY | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-14 | — | — | US | disclosed |
| US-5905149-A | CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND | PHARMACIA & UPJOHN S.P.A (IT) | 1999-05-18 | — | — | US | disclosed |
| US-5849710-A | Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-12-15 | — | — | US | disclosed |
| EP-0764152-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-03-26 | — | — | EP | disclosed |
| WO-1996032380-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-10-17 | — | — | WO | disclosed |
| EP-0457680-B1 | Derivatives of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde oxime, process for their preparation and their use as medicaments | ROUSSEL UCLAF (FR) | 1994-12-07 | — | — | EP | disclosed |
| EP-0457680-A1 | Derivatives of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde oxime, process for their preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1991-11-21 | — | — | EP | disclosed |