Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6549 | 0.91 | FFAR4 (0.45) | FFAR4LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL7562 | 0.84 | TSHR (0.39) | FFAR4LPAR1CCNCCDK8L3MBTL1 | |
| SCHEMBL6356 | 0.84 | LPAR1 (0.39) | FFAR4LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL6416 | 0.84 | LPAR1 (0.40) | LPAR1LPAR3S1PR1S1PR3ALDH1A1 | |
| SCHEMBL6779 | 0.79 | LPAR1 (0.42) | FFAR4LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL17265467 | 0.78 | PTGER4 (0.36) | FFAR4LPAR1CCNCCDK8REN | |
| SCHEMBL6889 | 0.77 | FFAR1 (0.46) | FFAR4LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL7540 | 0.77 | LPAR1 (0.43) | LPAR1LPAR3S1PR1S1PR3ALDH1A1 | |
| SCHEMBL7481 | 0.76 | LPAR1 (0.55) | FFAR4LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL6024 | 0.76 | LPAR1 (0.46) | LPAR1LPAR3S1PR1S1PR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |