Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242 | 0.91 | LIPG (0.44) | LPAR1S1PR1S1PR3LIPGPPARD | |
| SCHEMBL6415 | 0.86 | TP53 (0.40) | LPAR1PTPN1TP53VDRPPARD | |
| SCHEMBL6356 | 0.84 | LPAR1 (0.39) | LPAR1LPAR3S1PR1S1PR3L3MBTL1 | |
| SCHEMBL7563 | 0.84 | FFAR4 (0.39) | LPAR1LPAR3S1PR1S1PR3L3MBTL1 | |
| SCHEMBL6779 | 0.83 | LPAR1 (0.42) | LPAR1LPAR3PTPN1S1PR1S1PR3 | |
| SCHEMBL6889 | 0.82 | FFAR1 (0.46) | LPAR1LPAR3S1PR1S1PR3L3MBTL1 | |
| SCHEMBL7175 | 0.81 | LPAR1 (0.38) | LPAR1LPAR3S1PR1S1PR3HDAC1 | |
| SCHEMBL17265465 | 0.80 | PTPN1 (0.38) | LPAR1LPAR3PTPN1TP53LPAR2 | |
| SCHEMBL7481 | 0.79 | LPAR1 (0.55) | LPAR1LPAR3S1PR1S1PR3L3MBTL1 | |
| SCHEMBL6024 | 0.79 | LPAR1 (0.46) | LPAR1LPAR3S1PR1S1PR3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |