Sugi Predict

Sugi Predict / Compounds / Hydroxyamine

Hydroxyamine

Hydroxyamine

SCHEMBL7563754

NO.O=C(O)c1cnc2cc(C(F)(F)F)ccc2c1N(Cc1cccnc1)S(=O)(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 13/20 0.83
▸ MMP9 P14780 13/20 0.83
▸ MMP13 P45452 13/20 0.83
▸ ADAM17 P78536 9/20 0.83
▸ TRPM8 Q7Z2W7 5/20 0.47
▸ ADAMTS4 O75173 1/20 0.43
▸ PTGES O14684 1/20 0.42
▸ ALOX5 P09917 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxyamine SCHEMBL7532912 0.92 MMP1 (0.71) MMP1MMP9MMP13ADAM17TRPM8
SCHEMBL7563755 0.92 MMP1 (0.80) MMP1MMP9MMP13ADAM17TRPM8
SCHEMBL7009676 0.91 MMP1 (1.00) MMP1MMP9MMP13ADAM17
SCHEMBL7013919 0.89 MMP1 (0.77) MMP1MMP9MMP13ADAM17TRPM8
SCHEMBL7349080 0.88 MMP9 (0.84) MMP1MMP9MMP13ADAM17
SCHEMBL7010378 0.84 MMP13 (0.77) MMP1MMP9MMP13ADAM17TRPM8
Hydroxyamine SCHEMBL7382441 0.83 MMP1 (0.61) MMP1MMP9MMP13ADAM17TRPM8
SCHEMBL7532926 0.83 MMP1 (0.69) MMP1MMP9MMP13ADAM17
SCHEMBL6293309 0.82 MMP13 (0.85) MMP1MMP9MMP13ADAM17TRPM8
SCHEMBL7012284 0.82 MMP1 (0.84) MMP1MMP9MMP13ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998016514-A1 ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 — — WO disclosed