Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563064 | 0.98 | MAPT (0.36) | MAPTMEN1NPC1PABPC1RAB9A | |
| Bromide SCHEMBL27537591 | 0.83 | NOS2 (0.37) | MAPTMEN1NPC1PABPC1RAB9A | |
| SCHEMBL27537579 | 0.78 | NOS2 (0.37) | MAPTMEN1NPC1PABPC1RAB9A | |
| SCHEMBL2879873 | 0.77 | CCR1 (0.33) | CCR1HSP90AB1 | |
| Bromide SCHEMBL27537590 | 0.77 | NOS2 (0.36) | MAPTMEN1NPC1PABPC1RAB9A | |
| SCHEMBL2879516 | 0.76 | HSP90AB1 (0.56) | MAPTMEN1KMT2AHRH4HSP90AB1 | |
| SCHEMBL656121 | 0.74 | MAPT (0.50) | MAPTMEN1NPC1PABPC1RAB9A | |
| SCHEMBL7562734 | 0.74 | MAPT (0.34) | MAPTMEN1NPC1PABPC1RAB9A | |
| SCHEMBL9067684 | 0.74 | NOS2 (0.39) | MAPTNOS3NOS2TDP1CCR1 | |
| SCHEMBL6361284 | 0.74 | NOS2 (0.59) | NOS3NOS2HRH4HRH3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077981-B1 | NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME | LG CHEMICAL LTD (KR) | 2002-08-07 | — | — | EP | disclosed |
| EP-1077981-A1 | NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME | LG CHEMICAL LIMITED (KR) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058535-A1 | NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME | LG CHEMICAL LTD. (KR) | 1999-11-18 | — | — | WO | disclosed |