Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365773 | 0.90 | L3MBTL1 (0.35) | AKR1B1L3MBTL1KMT2ALMNAGAA | |
| SCHEMBL8359379 | 0.88 | AKR1B1 (0.33) | AKR1B1L3MBTL1KMT2AGAANLRP3 | |
| SCHEMBL8362191 | 0.88 | L3MBTL1 (0.34) | HDAC4AKR1B1L3MBTL1KMT2AGAA | |
| SCHEMBL8361432 | 0.88 | KMT2A (0.33) | AKR1B1L3MBTL1KMT2ALMNAOPRM1 | |
| SCHEMBL7571641 | 0.82 | NLRP3 (0.41) | HDAC4ALDH1A1KMT2AGAANLRP3 | |
| SCHEMBL7565508 | 0.81 | AKR1B1 (0.50) | AKR1B1ALDH1A1GAA | |
| SCHEMBL2697131 | 0.81 | AKR1B1 (0.42) | HDAC4AKR1B1ALDH1A1KMT2ALMNA | |
| SCHEMBL1340834 | 0.80 | KMT2A (0.35) | HDAC4ALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL8361242 | 0.77 | NOTUM (0.33) | L3MBTL1KMT2AGAANLRP3OPRM1 | |
| SCHEMBL8361234 | 0.77 | AKR1B1 (0.38) | AKR1B1L3MBTL1KMT2ALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987248-B1 | Amide derivatives and their therapeutic use | WELLCOME FOUND (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0699180-B1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | WELLCOME FOUND (GB) | 2000-11-22 | — | — | EP | disclosed |
| US-6124284-A | REDUCED SIDE EFFECTS | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0987248-A1 | Amide derivatives and their therapeutic use | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-22 | — | — | EP | disclosed |
| US-5872118-A | RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS | GLAXO WELLCOME INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0699180-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026693-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |
| WO-1994026692-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |