Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564435 | 0.88 | HDAC4 (0.35) | L3MBTL1AKR1B1OPRM1HDAC4KMT2A | |
| SCHEMBL8365773 | 0.88 | L3MBTL1 (0.35) | L3MBTL1AKR1B1OPRM1KMT2AGAA | |
| SCHEMBL8359379 | 0.85 | AKR1B1 (0.33) | L3MBTL1AKR1B1OPRM1KMT2AGAA | |
| SCHEMBL8362432 | 0.82 | AKR1B1 (0.48) | AKR1B1 | |
| SCHEMBL2697131 | 0.79 | AKR1B1 (0.42) | AKR1B1OPRM1HDAC4KMT2A | |
| SCHEMBL8361432 | 0.78 | KMT2A (0.33) | L3MBTL1AKR1B1OPRM1KMT2A | |
| SCHEMBL7564397 | 0.75 | AKR1B1 (0.39) | AKR1B1OPRM1HDAC4KMT2A | |
| SCHEMBL8361242 | 0.75 | NOTUM (0.33) | L3MBTL1OPRM1KMT2AGAANLRP3 | |
| SCHEMBL7571641 | 0.75 | NLRP3 (0.41) | HDAC4KMT2AGAANLRP3 | |
| SCHEMBL8361234 | 0.75 | AKR1B1 (0.38) | L3MBTL1AKR1B1OPRM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759026-B1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | WELLCOME FOUND (GB) | 1999-08-18 | — | — | EP | disclosed |
| US-5708033-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS OR ANALGESICS | GLAXO WELLCOME INC. (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0759026-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-02-26 | — | — | EP | disclosed |
| WO-1995030645-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |