Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB7A | P51149 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542803 | 1.00 | PARP1 (0.37) | PARP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7535281 | 0.91 | PARP1 (0.36) | PARP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7564422 | 0.90 | PARP1 (0.39) | PARP1POLBMEN1KMT2ARAB7A | |
| SCHEMBL5838018 | 0.85 | PTPN1 (0.42) | PARP1NR1I2UGCGMAPK1MAPT | |
| SCHEMBL5837463 | 0.85 | PTPN1 (0.42) | PARP1NR1I2UGCGMAPK1MAPT | |
| SCHEMBL5838412 | 0.85 | PTPN1 (0.42) | PARP1NR1I2UGCGMAPK1MAPT | |
| SCHEMBL5841257 | 0.82 | RAB7A (0.31) | RAB7A | |
| SCHEMBL7564276 | 0.79 | CYP1A2 (0.39) | MEN1KMT2AALDH1A1HTTRAB7A | |
| SCHEMBL7564931 | 0.77 | POLB (0.35) | PARP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL6399264 | 0.76 | ALDH1A1 (0.37) | POLBALDH1A1RAB7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |