Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564422 | 0.89 | PARP1 (0.39) | RAB7A | |
| SCHEMBL7564276 | 0.85 | CYP1A2 (0.39) | RAB7A | |
| SCHEMBL5837650 | 0.83 | PTPN1 (0.41) | — | |
| SCHEMBL5838719 | 0.83 | PTPN1 (0.41) | — | |
| SCHEMBL7564458 | 0.82 | PARP1 (0.37) | RAB7A | |
| SCHEMBL7542803 | 0.82 | PARP1 (0.37) | RAB7A | |
| SCHEMBL7535281 | 0.80 | PARP1 (0.36) | — | |
| SCHEMBL7701502 | 0.75 | HPGD (0.43) | RAB7A | |
| SCHEMBL5843765 | 0.74 | ALDH1A1 (0.38) | RAB7A | |
| SCHEMBL7699460 | 0.73 | NPC1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |