SCHEMBL7564674

SCHEMBL7564674

O=C(O)/C=C1/CCc2ccc(F)cc21

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.42
PARP10 Q53GL7 1/20 0.42
MAOB P27338 2/20 0.42
MAOA P21397 1/20 0.42
LOX P28300 1/20 0.42
SRD5A1 P18405 1/20 0.41
KDM4C Q9H3R0 1/20 0.38
CYP19A1 P11511 4/20 0.38
CYP11B1 P15538 3/20 0.38
CYP11B2 P19099 3/20 0.38
TRPA1 O75762 2/20 0.37
RXRA P19793 1/20 0.37
TYMS P04818 2/20 0.37
MAPK14 Q16539 1/20 0.36
PTAFR P25105 1/20 0.36
ACHE P22303 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7564681 1.00 PARP1 (0.42) PARP1PARP10MAOBMAOALOX
SCHEMBL7564661 1.00 PARP1 (0.42) PARP1PARP10MAOBMAOALOX
SCHEMBL7572139 0.90 RXRA (0.46) PARP1PARP10MAOBMAOALOX
SCHEMBL7572142 0.90 RXRA (0.46) PARP1PARP10MAOBMAOALOX
SCHEMBL7572145 0.90 RXRA (0.46) PARP1PARP10MAOBMAOALOX
SCHEMBL7564643 0.87 CYP11B2 (0.51) MAOBMAOALOXSRD5A1CYP19A1
SCHEMBL7564639 0.87 CYP11B2 (0.51) MAOBMAOALOXSRD5A1CYP19A1
SCHEMBL7564636 0.87 CYP11B2 (0.51) MAOBMAOALOXSRD5A1CYP19A1
SCHEMBL7567424 0.85 PARP1 (0.41) PARP1PARP10MAOBMAOALOX
SCHEMBL7567417 0.85 PARP1 (0.41) PARP1PARP10MAOBMAOALOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0987248-B1 Amide derivatives and their therapeutic use WELLCOME FOUND (GB) 2002-09-04 EP disclosed
EP-0699180-B1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS WELLCOME FOUND (GB) 2000-11-22 EP disclosed
US-6124284-A REDUCED SIDE EFFECTS GLAXO WELLCOME INC. (US) 2000-09-26 US disclosed
EP-0987248-A1 Amide derivatives and their therapeutic use THE WELLCOME FOUNDATION LIMITED (GB) 2000-03-22 EP disclosed
EP-0759025-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-07-21 EP disclosed
US-5872118-A RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS GLAXO WELLCOME INC. (US) 1999-02-16 US disclosed
US-5719186-A CENTRAL MUSCLE RELAXANTS, ANXIOLYTIC AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTICONVULSANTS GLAXO WELLCOME INC. (US) 1998-02-17 US disclosed
EP-0759025-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP disclosed
EP-0699180-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-06 EP disclosed
WO-1995030644-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO disclosed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed
WO-1994026693-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed