SCHEMBL7572142

SCHEMBL7572142

O=C(O)/C=C1/CCCc2ccc(F)cc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 4/20 0.46
PARP1 P09874 1/20 0.41
PARP10 Q53GL7 1/20 0.41
NPC1 O15118 4/20 0.40
RAB9A P51151 4/20 0.40
TP53 P04637 1/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CASP3 P42574 2/20 0.38
SENP7 Q9BQF6 2/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
LOX P28300 1/20 0.37
KDM4C Q9H3R0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7572145 1.00 RXRA (0.46) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL7572139 1.00 RXRA (0.46) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL7564661 0.90 PARP1 (0.42) RXRAPARP1PARP10MAOAMAOB
SCHEMBL7564681 0.90 PARP1 (0.42) RXRAPARP1PARP10MAOAMAOB
SCHEMBL7564674 0.90 PARP1 (0.42) RXRAPARP1PARP10MAOAMAOB
SCHEMBL6756016 0.86 MAOA (0.52) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL6756018 0.86 MAOA (0.52) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL6756019 0.86 MAOA (0.52) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL7573694 0.86 RXRA (0.40) RXRAPARP1PARP10NPC1RAB9A
SCHEMBL7573686 0.86 RXRA (0.40) RXRAPARP1PARP10NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0987248-B1 Amide derivatives and their therapeutic use WELLCOME FOUND (GB) 2002-09-04 EP disclosed
US-6124284-A REDUCED SIDE EFFECTS GLAXO WELLCOME INC. (US) 2000-09-26 US disclosed
EP-0987248-A1 Amide derivatives and their therapeutic use THE WELLCOME FOUNDATION LIMITED (GB) 2000-03-22 EP disclosed
EP-0759025-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-07-21 EP disclosed
US-5872118-A RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS GLAXO WELLCOME INC. (US) 1999-02-16 US disclosed
US-5719186-A CENTRAL MUSCLE RELAXANTS, ANXIOLYTIC AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTICONVULSANTS GLAXO WELLCOME INC. (US) 1998-02-17 US disclosed
EP-0759025-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP disclosed
EP-0699180-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-06 EP disclosed
WO-1995030644-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO disclosed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed
WO-1994026693-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed