Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL62422 | 0.98 | OPRL1 (0.69) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL31740265 | 0.89 | OPRL1 (0.57) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL31061425 | 0.83 | OPRM1 (1.00) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL75677 | 0.79 | OPRM1 (0.53) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| Hydrochloric Acid SCHEMBL61570 | 0.77 | OPRM1 (0.51) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL71724 | 0.76 | NPSR1 (0.57) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL28176312 | 0.76 | OPRM1 (0.51) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL1368994 | 0.75 | OPRM1 (0.49) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL14742155 | 0.74 | CYP3A4 (0.69) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| Hydrochloric Acid SCHEMBL2951072 | 0.74 | NPSR1 (0.56) | OPRL1OPRM1OPRK1OPRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180273553-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, INC. | 2018-09-27 | — | — | US | disclosed |
| US-10011616-B2 | Boron-containing small molecules as antiprotozoal1 agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2018-07-03 | — | — | US | disclosed |
| US-20180072760-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOALl AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2018-03-15 | — | — | US | disclosed |
| EP-3280717-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2018-02-14 | — | — | EP | disclosed |
| CN-107567456-A | Boron-containing small molecules as antiprotozoan agent | 安纳考尔医药公司 | 2018-01-09 | — | — | CN | disclosed |
| EP-1954277-B1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMA (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2016164814-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2016-10-13 | — | — | WO | disclosed |
| CN-102307869-B | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO.,LTD. (JP) | 2014-10-22 | — | — | CN | disclosed |
| US-20140141099-A1 | DRUG DISCOVERY METHODS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-05-22 | — | — | US | disclosed |
| US-8673891-B2 | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO., LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| US-20070259869-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-08 | — | — | US | disclosed |
| US-20070249031-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249031-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070179125-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
| US-20070179125-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
| WO-2007056221-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20050096297-A1 | Antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-05-05 | — | — | US | disclosed |
| US-20050096308-A1 | Antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-05-05 | — | — | US | disclosed |
| WO-2005026153-A1 | QUINAZOLINE-2, 4-DIONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| WO-2005026146-A1 | AZETIDINYL QUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011616-B2 | Boron-containing small molecules as antiprotozoal1 agents | HBS1L, DBNL, BOD1L1 | OPRL1 3811/4885OPRM1 4519/4885OPRK1 4609/4885 |
| US-20180072760-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOALl AGENTS | ABCB11, ABCB7, BRI3BP | OPRL1 4395/4885OPRM1 4310/4885OPRK1 4314/4885 |
| US-20070179125-A1 | Aminopyrimidines useful as kinase inhibitors | ABL1, MAP3K5, MAP3K20 | OPRL1 3870/4885OPRM1 4691/4885OPRK1 2425/4885 |
| US-20070259869-A1 | Aminopyrimidines useful as kinase inhibitors | ABL1, PRKDC, MAP3K5 | OPRL1 3894/4885OPRM1 4714/4885OPRK1 2473/4885 |
| US-20180273553-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | BTD, BAD, BRI3BP | OPRL1 4505/4885OPRM1 4380/4885OPRK1 4482/4885 |
| US-20050096297-A1 | Antibacterial agents | MRPL21, RPN2, FBL | OPRL1 1787/4885OPRM1 1670/4885OPRK1 1196/4885 |
| US-20140141099-A1 | DRUG DISCOVERY METHODS | AURKB, AURKC, AURKA | OPRL1 4326/4885OPRM1 4722/4885OPRK1 3672/4885 |
| US-20050096308-A1 | Antibacterial agents | MRPL21, RPN2, FBL | OPRL1 1787/4885OPRM1 1670/4885OPRK1 1196/4885 |
| US-20070249031-A1 | Aminopyrimidines useful as kinase inhibitors | ABL1, PRKDC, MAP3K5 | OPRL1 3894/4885OPRM1 4714/4885OPRK1 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.