Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.48 |
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSB | P07858 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.40 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561468 | 0.86 | CTSS (0.53) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5526075 | 0.85 | SMN1; SMN2 (0.52) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL7590963 | 0.85 | CTSL (0.50) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5525360 | 0.85 | CTSL (0.50) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5534117 | 0.83 | CTSS (0.70) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL7539083 | 0.83 | CTSL (0.55) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5530441 | 0.82 | CTSL (0.69) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5525335 | 0.82 | CTSL (0.69) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5534150 | 0.81 | CTSS (0.56) | CTSLCTSSCTSBCTSKCYP3A4 | |
| SCHEMBL7478526 | 0.80 | CTSL (0.48) | CTSLCTSSCTSBCTSKUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |