Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.50 |
| ▸ | CTSS | P25774 | 8/20 | 0.50 |
| ▸ | CTSB | P07858 | 6/20 | 0.50 |
| ▸ | CTSK | P43235 | 6/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | CTSH | P09668 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561468 | 0.88 | CTSS (0.53) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5526075 | 0.88 | SMN1; SMN2 (0.52) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5525360 | 0.88 | CTSL (0.50) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL7564797 | 0.85 | CTSL (0.48) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5525335 | 0.85 | CTSL (0.69) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5530441 | 0.85 | CTSL (0.69) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5523258 | 0.82 | CTSL (0.74) | CTSLCTSSCTSBCTSKSMN1; SMN2 | |
| SCHEMBL7478526 | 0.80 | CTSL (0.48) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL5518263 | 0.80 | CTSL (0.58) | CTSLCTSSCTSBCTSKUSP30 | |
| SCHEMBL7539158 | 0.80 | CTSL (0.55) | CTSLCTSSCTSBCTSKUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |