Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561473 | 0.86 | CTSK (0.48) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL5525920 | 0.85 | CTSL (0.46) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5529224 | 0.85 | NPC1 (0.50) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5523266 | 0.84 | CTSK (0.47) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL5525371 | 0.84 | RAB9A (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5526078 | 0.84 | CTSL (0.47) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL5527661 | 0.83 | CTSL (0.57) | CTSLCTSBCTSSCTSKDPP4 | |
| SCHEMBL5525342 | 0.82 | CTSL (0.60) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL5520555 | 0.82 | KCNA3 (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5526253 | 0.82 | HPGD (0.51) | CTSLCTSBCTSSCTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |