Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277518 | 0.81 | TSHR (0.44) | TSHRMAPK1ALDH1A1TDP1CYP1A2 | |
| SCHEMBL7136409 | 0.75 | CA2 (0.41) | TSHRALDH1A1TDP1CYP1A2ALOX15 | |
| SCHEMBL27968179 | 0.72 | ALDH1A1 (0.44) | TSHRALDH1A1TDP1CYP1A2ALOX15 | |
| SCHEMBL8019320 | 0.72 | TSHR (0.48) | TSHRMAPK1ALDH1A1TDP1CYP1A2 | |
| Chlorotriphenylmethane SCHEMBL461 | 0.69 | TSHR (0.65) | TSHRMAPK1ALDH1A1CYP1A2TAAR1 | |
| Chlorotriphenylmethane SCHEMBL16781670 | 0.69 | TSHR (0.65) | TSHRMAPK1ALDH1A1CYP1A2TAAR1 | |
| SCHEMBL28506719 | 0.69 | ALDH1A1 (0.35) | TSHRMAPK1ALDH1A1TDP1ESR2 | |
| SCHEMBL13521990 | 0.69 | KCNN4 (0.48) | TSHRMAPK1ALDH1A1TDP1CYP1A2 | |
| SCHEMBL3801446 | 0.68 | TSHR (0.44) | TSHRMAPK1ALDH1A1CYP1A2TAAR1 | |
| Tert-Butylbenzene SCHEMBL28171385 | 0.68 | TSHR (0.55) | TSHRMAPK1ALDH1A1TDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741741-B1 | MODIFIED OLIGONUCLEOTIDES | NOVARTIS AG (CH) | 2002-08-28 | — | — | EP | disclosed |
| US-6066447-A | INCLUDING NUCLEOSIDE DIMERS WITH MODIFIED BACKBONES; FOR VIRICIDES AND ANTISENSE AGENTS | NOVARTIS CORPORATION (US) | 2000-05-23 | — | — | US | disclosed |
| EP-0741741-A1 | MODIFIED OLIGONUCLEOTIDES | Novartis AG (CH) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020597-A1 | MODIFIED OLIGONUCLEOTIDES | CIBA-GEIGY AG (CH) | 1995-08-03 | — | — | WO | disclosed |