Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260367 | 0.78 | ALOX15 (0.50) | KDM4EKMT2AMGAMMEN1LMNA | |
| SCHEMBL9756635 | 0.78 | MGAM (0.55) | KDM4EKMT2AMGAMMEN1LMNA | |
| SCHEMBL2450006 | 0.77 | MGAM (0.47) | KDM4EKMT2AMGAMMEN1LMNA | |
| SCHEMBL1094226 | 0.76 | LMNA (0.59) | KDM4EKMT2AMGAMMEN1LMNA | |
| SCHEMBL1088781 | 0.73 | KDM4E (0.67) | KDM4EKMT2AMGAMMEN1LMNA | |
| SCHEMBL30432091 | 0.72 | EGFR (0.47) | LMNACSNK2A1 | |
| SCHEMBL1096307 | 0.72 | EGFR (0.47) | LMNACSNK2A1 | |
| SCHEMBL5564401 | 0.71 | KDM4E (0.56) | KDM4EKMT2AMGAMMEN1LMNA | |
| Hydrochloric Acid SCHEMBL10553456 | 0.71 | KDM4E (0.64) | KDM4EKMT2AMGAMMEN1LMNA | |
| Benzene SCHEMBL27872024 | 0.71 | KDM4E (0.70) | KDM4EKMT2AMGAMMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203586-A2 | Compositions comprising a mast cell degranulation-blocking agent for treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin. | KOS PHARMACEUTICALS, INC. (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-0618796-B1 | ALLEVIATING OR PREVENTION OF MIGRAINE HEADACHE ONSET WITH MAST CELL DEGRANULATION BLOCKING AGENTS | KOS PHARMA INC (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5648355-A | MAST CELL DEGRANULATION-BLOCK AGENTS | KOS PHARMACEUTICAL, INC. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5250529-A | Administering during prodrome phase in absence of analgesic | KOS PHARMACEUTICALS, INC. (US) | 1993-10-05 | — | — | US | disclosed |