Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7566166

CC(C)c1ccccc1C1=C([Zr+2]C2=C(c3ccccc3C(C)C)C=CC2)CC=C1.[Cl-].[Cl-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.31
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CA12 O43570 1/20 0.37
CA9 Q16790 1/20 0.37
GABRA1 P14867 2/20 0.33
GABRB2 P47870 2/20 0.33
FAAH O00519 2/20 0.31
MGLL Q99685 1/20 0.31
TRPA1 O75762 1/20 0.31
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
GABRB1 P18505 1/20 0.31
GABRG2 P18507 1/20 0.31
PTGS1 P23219 1/20 0.31
HTR2C P28335 1/20 0.31
GABRB3 P28472 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7566924 0.79 NISCH (0.35) CA1CA2CA12CA9TSHR
Hydrochloric Acid SCHEMBL27515128 0.78 CA1 (0.35) CA1CA2CA12CA9GABRA1
Hydrochloric Acid SCHEMBL27515129 0.75 CA1 (0.35) CA1CA2CA12CA9GABRA1
SCHEMBL9065916 0.75 CA1 (0.35) CA1CA2CA12CA9GABRA1
Hydrochloric Acid SCHEMBL7566172 0.73 CA1 (0.34) CA1CA2CA12CA9GABRA1
SCHEMBL29002030 0.71 CA12 (0.33) CA1CA2CA12CA9GABRA1
SCHEMBL167078 0.69 GABRA1 (0.55) CA1CA2CA12CA9GABRA1
SCHEMBL29414063 0.69 GABRA1 (0.55) CA1CA2CA12CA9GABRA1
SCHEMBL9174922 0.66 GABRA1 (0.52) CA1CA2CA12CA9GABRA1
Hydrochloric Acid SCHEMBL617245 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540108-B1 Catalyst composition SHELL INT RESEARCH (NL) 1996-01-03 EP claimed
US-5279999-A Catalyst composition SHELL OIL COMPANY (US) 1994-01-18 US claimed
EP-0540108-A1 Catalyst composition SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1993-05-05 EP claimed
WO-2002083747-A2 PROCESS FOR THE PREPARATION OF A POLYMER-AMINE SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2002-10-24 WO disclosed
US-5279999-A Catalyst composition SHELL OIL COMPANY (US) 1994-01-18 US disclosed