Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 4/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566311 | 1.00 | TRPA1 (0.38) | TRPA1PPARGACHEBCHEAKR1B1 | |
| SCHEMBL7566305 | 1.00 | TRPA1 (0.38) | TRPA1PPARGACHEBCHEAKR1B1 | |
| SCHEMBL7566372 | 0.90 | TRPA1 (0.36) | TRPA1PPARGACHEAKR1B1 | |
| SCHEMBL7566360 | 0.90 | TRPA1 (0.36) | TRPA1PPARGACHEAKR1B1 | |
| SCHEMBL7566366 | 0.90 | TRPA1 (0.36) | TRPA1PPARGACHEAKR1B1 | |
| SCHEMBL8151561 | 0.88 | MAOA (0.41) | TRPA1PPARGACHEBCHEKIF11 | |
| SCHEMBL8151562 | 0.88 | MAOA (0.41) | TRPA1PPARGACHEBCHEKIF11 | |
| SCHEMBL7565999 | 0.88 | ACHE (0.33) | TRPA1PPARGACHEBCHEKIF11 | |
| SCHEMBL8151560 | 0.88 | MAOA (0.41) | TRPA1PPARGACHEBCHEKIF11 | |
| SCHEMBL7565987 | 0.88 | ACHE (0.33) | TRPA1PPARGACHEBCHEKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987248-B1 | Amide derivatives and their therapeutic use | WELLCOME FOUND (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0699180-B1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | WELLCOME FOUND (GB) | 2000-11-22 | — | — | EP | disclosed |
| US-6124284-A | REDUCED SIDE EFFECTS | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0987248-A1 | Amide derivatives and their therapeutic use | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-22 | — | — | EP | disclosed |
| US-5872118-A | RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS | GLAXO WELLCOME INC. (US) | 1999-02-16 | — | — | US | disclosed |
| WO-1994026692-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |