Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 9/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564602 | 0.87 | MAOB (0.40) | HTR2CMAOBSIGMAR1PSMB5 | |
| SCHEMBL7564413 | 0.85 | HTR2C (0.39) | HTR2CMAOBSIGMAR1PSMB5PDE5A | |
| SCHEMBL7566314 | 0.77 | RIPK1 (0.32) | — | |
| SCHEMBL5156270 | 0.72 | MAOB (0.43) | MAOBOPRK1 | |
| SCHEMBL15094741 | 0.69 | ACHE (0.50) | HTR2CMAOB | |
| SCHEMBL10977287 | 0.69 | MAOB (0.44) | MAOB | |
| SCHEMBL28108222 | 0.69 | ACHE (0.39) | HTR2CMAOB | |
| SCHEMBL27953676 | 0.69 | FFAR1 (0.43) | MAOBSIGMAR1PDE5A | |
| SCHEMBL7563771 | 0.67 | ACHE (0.44) | HTR2CMAOB | |
| SCHEMBL503654 | 0.66 | SIGMAR1 (0.57) | MAOBSIGMAR1PSMB5PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987248-B1 | Amide derivatives and their therapeutic use | WELLCOME FOUND (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0699180-B1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | WELLCOME FOUND (GB) | 2000-11-22 | — | — | EP | disclosed |
| US-6124284-A | REDUCED SIDE EFFECTS | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0987248-A1 | Amide derivatives and their therapeutic use | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-22 | — | — | EP | disclosed |
| US-5872118-A | RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS | GLAXO WELLCOME INC. (US) | 1999-02-16 | — | — | US | disclosed |
| CN-1041720-C | Bicyclic amide derivatives, preparation method thereof, pharmaceutical composition and pharmaceutical application thereof | WELLCOME FOUND (GB) | 1999-01-20 | — | — | CN | disclosed |
| CN-1125938-A | Bicyclic amide derivatives and their use as muscle relaxants | WELLCOME FOUND (GB) | 1996-07-03 | — | — | CN | disclosed |
| EP-0699180-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026692-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |
| WO-1994026693-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |