Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7579847 | 0.86 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL104545 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL19705361 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL18844888 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL22369902 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL7776775 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL19966112 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL278463 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| SCHEMBL23319701 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 | |
| Hydrochloric Acid SCHEMBL2863718 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EEPHX1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183561-A1 | PROCESS FOR PREPARING POLYETHER POLYOLS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-05 | — | — | US | disclosed |
| WO-2002090420-A2 | METHOD FOR PRODUCING POLYETHER POLYOLS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-14 | — | — | WO | disclosed |
| US-6469218-B1 | POLYADDITION OF ALKYLENE OXIDES ON TO STARTER COMPOUNDS CONTAINING ACTIVE HYDROGEN ATOMS UNDER BASIC CATALYSIS IN THE PRESENCE OF PHOSPHONIUM CATIONS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183561-A1 | PROCESS FOR PREPARING POLYETHER POLYOLS | PHOSPHO1, SQLE, PUF60 | ALDH1A1 4158/4885HSD17B10 172/4885KDM4E 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.