Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.33 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DTYMK | P23919 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7566851 | 1.00 | HTR1A (0.34) | HTR1ASLC6A4GPR119DRD2HTR2A | |
| SCHEMBL7496096 | 0.85 | HTR1A (0.34) | HTR1ASLC6A4DRD2HTR2AKDM1A | |
| SCHEMBL7496094 | 0.85 | HTR1A (0.34) | HTR1ASLC6A4DRD2HTR2AKDM1A | |
| Succinic Acid SCHEMBL6593898 | 0.81 | HTR1A (0.39) | HTR1ASLC6A4DRD2HTR2A | |
| Succinic Acid SCHEMBL6593881 | 0.81 | HTR1A (0.39) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL6594649 | 0.80 | DTYMK (0.43) | GPR119KDM1ADTYMKALOX15TSHR | |
| SCHEMBL17080911 | 0.74 | GPR119 (0.46) | GPR119DTYMKKDM4EPKMHPGDS | |
| SCHEMBL6596667 | 0.72 | SLC6A4 (0.41) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL6595007 | 0.72 | SLC6A4 (0.41) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL6596677 | 0.72 | SLC6A4 (0.41) | HTR1ASLC6A4DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204660-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009126-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |