Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598647 | 0.83 | KDM1A (0.39) | DTYMKGPR119KDM1A | |
| SCHEMBL15380793 | 0.83 | HDAC4 (0.44) | GPR119PDK2HDAC1HDAC8HDAC6 | |
| Succinic Acid SCHEMBL7566854 | 0.80 | HTR1A (0.34) | DTYMKGPR119TSHRALOX15ATM | |
| Succinic Acid SCHEMBL7566851 | 0.80 | HTR1A (0.34) | DTYMKGPR119TSHRALOX15ATM | |
| SCHEMBL17996847 | 0.80 | DTYMK (0.48) | DTYMKGPR119GBA1 | |
| SCHEMBL7492376 | 0.79 | SLC6A1 (0.34) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL14143335 | 0.78 | CHRM2 (0.42) | GPR119PDK2HDAC1HDAC8HDAC6 | |
| SCHEMBL14143343 | 0.78 | JAK1 (0.44) | GPR119PDK2HDAC1HDAC8HDAC6 | |
| SCHEMBL3249913 | 0.78 | OPRD1 (0.49) | GPR119PDK2HDAC1HDAC8HDAC6 | |
| SCHEMBL429502 | 0.77 | POLB (0.47) | DTYMKGPR119PDK2HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204660-B1 | SEROTONERGIC BENZOTHIOPHENES | LILLY CO ELI (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1204660-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009126-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |