Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041470 | 0.83 | POLB (0.77) | MEN1KMT2ASIGMAR1SLC6A12POLB | |
| SCHEMBL4034750 | 0.82 | MEN1 (0.67) | MEN1KMT2ASIGMAR1SLC6A12POLB | |
| SCHEMBL17946338 | 0.80 | KMT2A (0.80) | MEN1KMT2ASIGMAR1SLC6A12DRD4 | |
| SCHEMBL6312739 | 0.79 | SIGMAR1 (0.76) | MEN1KMT2ASIGMAR1SLC6A12MAPT | |
| SCHEMBL4039743 | 0.78 | MEN1 (0.64) | MEN1KMT2ASIGMAR1SLC6A12POLB | |
| SCHEMBL9591760 | 0.77 | KMT2A (0.83) | MEN1KMT2ASIGMAR1POLBDRD4 | |
| SCHEMBL2213082 | 0.77 | SIGMAR1 (0.76) | MEN1KMT2ASIGMAR1MCHR1 | |
| SCHEMBL29827636 | 0.76 | SLC6A12 (1.00) | SIGMAR1SLC6A12POLBDRD4 | |
| SCHEMBL12511819 | 0.76 | SIGMAR1 (0.70) | MEN1KMT2ASIGMAR1MAPTMCHR1 | |
| SCHEMBL4976899 | 0.76 | SIGMAR1 (0.70) | MEN1KMT2ASIGMAR1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca UK Limited (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014333-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |