Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.60 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.56 |
| ▸ | PNP | P00491 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | HBB | P68871 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982329 | 0.88 | TK1 (0.57) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL7575116 | 0.87 | TK1 (0.59) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL7570078 | 0.87 | TK1 (0.65) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL7570457 | 0.87 | TK1 (0.56) | TK1HPRT1PNPBLM | |
| SCHEMBL7576803 | 0.85 | TK1 (0.60) | TK1HPRT1PNP | |
| SCHEMBL7572289 | 0.84 | TK1 (0.60) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL7589923 | 0.84 | TK1 (0.57) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL7575081 | 0.84 | TK1 (0.55) | TK1HPRT1PNP | |
| SCHEMBL7567140 | 0.83 | PNP (0.64) | TK1HPRT1PNPUSP2TSHR | |
| SCHEMBL5250164 | 0.83 | TK1 (0.68) | TK1HPRT1PNPUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237890-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029039-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2001-04-26 | — | — | WO | claimed |