Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.60 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.60 |
| ▸ | PNP | P00491 | 5/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EDNRA | P25101 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HBB | P68871 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570078 | 0.94 | TK1 (0.65) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7982329 | 0.87 | TK1 (0.57) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7575116 | 0.87 | TK1 (0.59) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7567140 | 0.87 | PNP (0.64) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7576803 | 0.85 | TK1 (0.60) | TK1HPRT1PNP | |
| SCHEMBL7402410 | 0.84 | HPRT1 (0.57) | HPRT1PNP | |
| SCHEMBL7567095 | 0.84 | TK1 (0.60) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7574815 | 0.83 | BLM (0.57) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7589923 | 0.81 | TK1 (0.57) | TK1HPRT1PNPBLMUSP2 | |
| SCHEMBL7567195 | 0.80 | HPRT1 (0.51) | TK1HPRT1PNPBLMUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237890-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2002-09-11 | — | — | EP | claimed |
| US-6297226-B1 | TREATING A DISEASE OR A CONDITION IN A MAMMAL TREATABLE BY INHIBITING THE ACTIVITY OF A MONOAMINE OXIDASE | NEOTHERAPEUTICS, INC. | 2001-10-02 | — | — | US | claimed |
| WO-2001029039-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| US-6297226-B1 | TREATING A DISEASE OR A CONDITION IN A MAMMAL TREATABLE BY INHIBITING THE ACTIVITY OF A MONOAMINE OXIDASE | NEOTHERAPEUTICS, INC. | 2001-10-02 | — | — | US | disclosed |