Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566458 | 0.86 | AOX1 (0.52) | HDAC1HDAC6AOX1TP53RAD52 | |
| SCHEMBL7107762 | 0.84 | AOX1 (0.65) | HDAC1HDAC6AOX1PARP1RAD52 | |
| SCHEMBL7573617 | 0.83 | HDAC1 (0.49) | HDAC1HDAC6AOX1RAD52TSHR | |
| SCHEMBL8624357 | 0.83 | HDAC1 (0.49) | HDAC1HDAC6AOX1RAD52TSHR | |
| SCHEMBL8413595 | 0.81 | AOX1 (0.54) | HDAC1HDAC6AOX1HDAC3RAD52 | |
| SCHEMBL8412027 | 0.81 | AOX1 (0.48) | HDAC1HDAC6AOX1TP53BP1RAD52 | |
| SCHEMBL8415169 | 0.81 | HDAC1 (0.47) | HDAC1HDAC6AOX1TP53RAD52 | |
| SCHEMBL7570699 | 0.79 | HDAC1 (0.45) | HDAC1HDAC6AOX1RAD52TSHR | |
| SCHEMBL7572168 | 0.77 | AOX1 (0.57) | HDAC1HDAC6AOX1RAD52MEN1 | |
| SCHEMBL7570661 | 0.77 | AOX1 (0.57) | HDAC1HDAC6AOX1TP53BP1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934278-B1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LTD (GB) | 2002-09-04 | — | — | EP | claimed |