Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430235 | 0.82 | KMT2A (0.57) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL27474928 | 0.79 | NPC1 (0.59) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL8473023 | 0.79 | MEN1 (0.65) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL438214 | 0.77 | RAB9A (0.70) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL16264397 | 0.77 | MEN1 (0.50) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL7565219 | 0.75 | NAMPT (0.66) | KMT2AMEN1KDM4ESMN1; SMN2MAPK8 | |
| SCHEMBL17903899 | 0.74 | CYP2C9 (0.66) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL1844028 | 0.74 | NPC1 (0.60) | KMT2AMEN1L3MBTL1KDM4ENPC1 | |
| SCHEMBL1680689 | 0.72 | PTK2 (0.73) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30339171 | 0.72 | MEN1 (0.69) | KMT2AMEN1L3MBTL1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261600-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | claimed |
| WO-2001058890-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | claimed |