Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13164049 | 0.80 | NAMPT (1.00) | NAMPTLMNAHTTPTBP1KLF5 | |
| SCHEMBL162008 | 0.78 | RAB9A (0.65) | NAMPTLMNAHTTALDH1A1MEN1 | |
| SCHEMBL29655934 | 0.78 | RAB9A (0.65) | NAMPTLMNAHTTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL27677130 | 0.76 | RAB9A (0.62) | NAMPTLMNAHTTALDH1A1MEN1 | |
| SCHEMBL2155229 | 0.75 | MAPK8 (0.70) | LMNASMN1; SMN2MAPK8ALDH1A1MEN1 | |
| SCHEMBL7567658 | 0.75 | KMT2A (0.54) | SMN1; SMN2MAPK8MEN1KMT2AKDM4E | |
| SCHEMBL29099760 | 0.75 | ALDH1A1 (0.70) | NAMPTLMNAHTTALDH1A1MEN1 | |
| SCHEMBL20303176 | 0.74 | NAMPT (0.71) | NAMPTLMNAHTTPTBP1KLF5 | |
| Boric Acid SCHEMBL29121086 | 0.74 | RAB9A (0.59) | NAMPTLMNAHTTALDH1A1MEN1 | |
| SCHEMBL1848072 | 0.73 | LMNA (0.62) | NAMPTLMNAHTTPTBP1KLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261600-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | claimed |
| WO-2001058890-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | claimed |