Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.73 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.73 |
| ▸ | POLB | P06746 | 7/20 | 0.46 |
| ▸ | RAD52 | P43351 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564523 | 0.93 | TOP2A (0.71) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7563689 | 0.89 | TOP2A (0.77) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL3981533 | 0.89 | TOP2A (0.80) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7562964 | 0.89 | TOP2A (0.71) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7563941 | 0.89 | TOP2A (0.62) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL3985960 | 0.88 | TOP2A (0.59) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL6546437 | 0.86 | TOP2A (0.76) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7568574 | 0.86 | TOP2A (0.73) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7567330 | 0.86 | TOP2A (0.73) | TOP2ATOP2BPOLBRAD52KMT2A | |
| SCHEMBL7567582 | 0.86 | TOP2A (0.73) | TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020111491-A1 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111491-A1 | 9-aminoacridine derivatives and process for the preparation thereof | ALKBH1, ADCY9, CCR9 | TOP2A 1105/4885TOP2B 841/4885POLB 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.