SCHEMBL7568017

SCHEMBL7568017

Cc1csc(C2=C(c3ccccc3)C(=O)C2(C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 6/20 0.47
PTGS2 P35354 5/20 0.47
BACE1 P56817 1/20 0.33
MAPT P10636 2/20 0.32
TP53 P04637 1/20 0.32
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
DAO P14920 1/20 0.31
PDE4B Q07343 1/20 0.31
ALOX5 P09917 1/20 0.31
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
ALOX15 P16050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7573867 0.88 PTGS1 (0.47) PTGS1PTGS2BACE1DAOSMN1; SMN2
SCHEMBL7565479 0.85 PTGS2 (0.35) PTGS1PTGS2MAPTTP53GABRA1
SCHEMBL6326345 0.84 PTGS1 (0.34) PTGS1PTGS2BACE1MAPTTP53
SCHEMBL72613 0.73 AR (0.43) DAONPC1RAB9ASMN1; SMN2TSHR
SCHEMBL7565538 0.72 PTGS1 (0.33) PTGS1PTGS2
SCHEMBL7566081 0.72 PTGS1 (0.46) PTGS1PTGS2BACE1MAPTTP53
SCHEMBL5833325 0.71 KMT2A (0.56) PTGS1PTGS2ALDH1A1SMN1; SMN2
SCHEMBL7569141 0.70 PTGS1 (0.37) PTGS1PTGS2BACE1ALDH1A1CHEK1
SCHEMBL7566050 0.70 ALDH2 (0.32) BACE1MAPTTP53DAOPDE4B
SCHEMBL7259290 0.69 PTGS2 (0.53) PTGS1PTGS2MAPTPDE4BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889878-B1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC (CA) 2002-09-04 EP claimed
US-5817700-A ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1998-10-06 US claimed
EP-0889878-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1999-01-13 EP disclosed
US-5817700-A ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1998-10-06 US disclosed
WO-1997036863-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-10-09 WO disclosed